A Comparative Clinical Evaluation of Raktadabashamak Ghana Vati and Sarpagandha Ghana Vati in the Management of Essential Hypertension

Abstract

Hypertension is one of the major causes of disability and death all over the world. Considering its increasing prevalence and development of drug resistance a clinical study entitled “A comparative clinical evaluation of Raktadabashamak Ghana Vati and Sarpagandha Ghana Vati in the management of Essential Hypertension” was undertaken in 60 hypertensive patients for 2 months. On administration of 2 tablets of Sarpagandha Ghana vati (250 mg each) twice daily after meals with luke warm water in 20 patients, mean % relief in Systolic Blood Pressure was 11.3%, Diastolic Blood Pressure was reduced by 10.7%, Pulse rate was reduced by 17.01%, Pulse pressure was reduced by 8.9%, Mean arterial Pressure was reduced by 12.09% which were all statistically highly significant. Results obtained with Raktadabashamak Ghana Vati (250 mg each)2 tablets twice daily after meals with luke warm water on 18 patients were 18.6% relief in Systolic Blood Pressure, 18.5% relief in Diastolic Blood Pressure, 9.3% relief in Pulse rate, 18.8% relief in Pulse pressure, 19.05% relief in Mean Arterial Pressure which were all statistically highly significant. Overall response of Raktadabashamak Ghana vati was excellent in 17.6% patients and marked improvement in 41.1% Patients, it was better than overall response of Sarpagandha Ghana Vati which showed only mild improvement in maximum (80%) patients. Remission of treatment lead to increase in Blood pressure However, Study should be repeated by taking sample with longer duration to see whether the recurrence of disease in follow ups has decreased or not.

References

1. Raghupathy Anchala, Nandak Kannuri, et al., Jun 2014, J Hypertension 32 (6): 1170 1177, doi10.1097/HJH.0000000000000146, retrieved from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011565.
2. Arshiya Ali,Management of Essential Hypertension vis-à-vis Raktachapadhikya - A clinical study, (MD Thesis).Rajiv Gandhi University of Health Sciences, Karnataka,2013.
3. Aram V. Chobanian, George L.Bakris, Henry R. Black, William C.Cushman, Lee A.G.(2003) : 7th report of the jont national committee on prevention,evaluation and treatment of high blood pressure1211p.
4. Siddha yoga Sangraha, Vaidya yadav ji trikam ji, 2012, 100p.
5. Mahajan, B.K (1997): Methods in Biostatics.Jaypee brothers Medical publishers,New Delhi.
6. Dr. K. M. Nadakarni, Indian Meteria Medica, Vol2, Popular Prakashan, Reprint 2007, 1051p.
7. Dr. K. M. Nadakarni, Indian Meteria Medica, Vol2, Popular Prakashan, Reprint 2007, 1052p.
8. Murray B Sheldon, J.Harold Kotte, Effect of Rauwolfia serpentina and Reserpine on the Blood Pressure in Essential Hypertension. AHA journals, 1957, retrieved from http://circ.ahajournals.org on 1 March 2016.
9. Dravyaguna Vignan Volume II by Prof. P.V. Sharma, Reprint Edition-2001, Chaukhambha Bharti Academy, 51-53.
10. BhavMishra,Bhav Prakash Nighantu, commentary by Dr.K C Chunekar, Chaukhamba Bharti, Reprint 2006,29p.
11. Dravyaguna Vignan Volume II by Prof. P.V. Sharma, Reprint Edition-2001, Chaukhambha Bharti Academy, 31-35.
12. Purnima, Bhatt Meenakshi and Kothiyal Preeti.A review article on phytochemistry and pharmacological profiles of Nordostachys jatamansi DC-medicinal herb, Journal of pharmacognosy and phytochemistry.2015.3(5):102-106.
13. Dravyaguna Vignan Volume II by Prof. P.V. Sharma, Reprint Edition-2001,Chaukhambha Bharti Academy,25-28.
14. DravyagunaVignan Volume II by Prof. P.V. Sharma, Reprint Edition 2001,ChaukhambhaBharti Academy,275-279.
15. Charaka,vyakyakar Pt.Kashinath Shastri, Dr.Gorakhnath Chaturvedi, Charak samhita Varanasi, chaukhamba bharati publications,2009,sutra sthana(25/40),468p.
16. Kumari M,Ashok BK ,et al.,Anti inflammatory action of two varieties of Pippali (Piper longum linn.), AYU 2012,33: 307-10, retrieved from http://www.ayujournal.org.
17. Dravyaguna Vignan Volume II by Prof. P.V. Sharma, Reprint Edition 2001,ChaukhambhaBharti Academy,632-634.
18. Bhavmishra, commentary by Pandey Ganga Sahay, Chunekar K.C.Bhavprakash Nighantu, Chaukhamba bharti publications, Varanasi.2006.p.292.
19. Murthy A.R., Dubey S.D, Tripathy K.Anti-hypertensive effect of Gokshur (Tribulus Terrestris Linn.) A clinical study, Ancient science of life.2000. 11(4):139-145.
20. Dravyaguna Vignan Volume II by Prof. P.V. Sharma, Reprint Edition-2001, ChaukhambhaBharti Academy, 195-197.
21. R H Patl et al., hypolipidemic effects of Terminalia arjuna (L.) in experimentally induced hyperlipidemic rats J Acta Biologica,55(2):289-293,2011 retreived from http://www.sci.u sceged.hu/ABS.
22. G.M. Hussain,Deepa Mishra,et al., Ethnopharmacological review of native traditional medicinal plants for brain disorders of Pharmacognosy review.2007.1(1):19-29.
23. Dravyaguna Vignan Volume II by Prof. P.V. Sharma, Reprint Edition 2001, ChaukhambhaBharti Academy, 28-30.
24. Jabbar shah A, Gilani A. Blood pressure lowering and vascular modulator effects of Acorus calamus extracts are mediated through multiple pathways, Journal of cardiovascular pharmacology.2009. 54(1):38-46.
25. Kumar Gaurav, Mehra B.L, et al., A.Clinical study to assess the effect of uchhaRaktachaphar yoga in essential hypertension. Journal of applied Pharmaceutical Science.2015 3(2):8-13